30th May 1997Nihon univ.Dent.Journal

Analysis of Mouse Secretory Component Genomic DNA

                                 Hiroshi Fujita

Nihon University School of Dentistry ,Major in Oral and Maxillofacial Surgery.

(Director :Prof.Itsuro Kudo)



The polymeric immnoglobulin receptor tranports polymeric immnoglobulin A and M across the glandlar epitherial cells 1).During this process ,the receptor ,an integral membrane protein ,is cleaved by proteolytic enzyme with the result that a large portion known as the secretory component (SC) is released as external secretion with the immnoglobulins.2.3)

In this study,mouse genomic library was sceened by EcoR I fragment of the mouse SC cDNA clone to determine the mouse SC genome. The following result were obtained:

1.Approximatery  1.0kb and 580bp introns spanned positions 1041bp and positions 1375bp and 1376bp of mouse SC cDNA ,respecttively.

2The genomic organization (exon-intron structures)and exon seqences were very close for human and mouse SC.



1) Mostov,K,E&Simister,N,E:Trancytosis;Cell,43,p389-390,1985

2 )Kuhn,L.C&Kraehenbuhl,J-P:The membrane receptor for polymeric immno globulin is      structuaraly rerated to secretory component; Biochemistry,23,p12490-12495,1981

3)Mestecky,j.,Lue,C&Russel,M.W.:Selective transport of IgA:Cellular and molecular     aspects;Gastroenterol.Clinics of North America.,20,,p441-450







16th March 2008 reserchreport abstract

The experience and  prognosis of generative procedure

using EMD
                                         Hiroshi Fujita

 Director of Fujita dental clinic, Business faculty of Nihon University.


There are many methods  of periodontal surgical therapy and past research revealed ordinary surgical procedure didnft get attachment adhesion of the gum1).

Some method like Guided Tissue Regeneration (GTR) revealed that Gum were healed by controlled tissue regeneration but also these method didnft get attachment of the gum2)3) .

Regeneration method@using Enamel matrix protein confirm true periodontal regeneration4)5) .

This report is showing simple process with  appropriate regenerative operation and these prognosis

Please evaluate yourself and compare with your cases!!



1)Histometricevaluation of periodontal surgery connective tissue attachment levels of four generative procedure Carton.J et al Journal of clinical periodontology 7:224-231

2)EMD in the treatement of intrabony periodontal defectL..heiji et al ,Journal of clinical periodontology 1997 24:705-714

3)The periodontal tissues in healed degree III furcation defect(an experimental study in dogs)M.araujo alJournal of clinical periodontology 1996 23:532-541

4)Enamel matrix ,cementum development and regeneration Lars Hammarstrom et al ,Journal of clinical periodontology 1997 24:658-668

5)@periodontal regeneration a buccal dehiscence model in monkeys afterapplication of enamel matrix proteins ,Lars Hammarstrom et al ,Journal of clinical periodontology 1997 24:669-677

6)Comparison of ready to use EMD gel and dlc in patients with chronic adult periodontitis,Bratthall et al ,Journal of clinical periodontology 2001 28:923-929

7)Reaction of oral tissue to suture material Lilly GE Oral surgery Oral medicine oral pathology 26 128-133

8)Effect of professional tooth cleaning on healing after periodontalsurgery Jan Lindhe et al, Lars Hammarstrom et al ,Journal of clinical periodontology 1975 2:80-86

9)Pain experienced by patients under going different periodontal therapies  Cenk Faith Canaski,DDS,PhD; Varol Canakci,DDS, PhD,The journal of Tthe American dental association December 2007, p1563-1573